I would love to see Orochimaru in Ryslig! It's a fairly dark game where you slowly start transforming into one of a variety of monsters after you arrive. The AC is 20 comments a month with bonuses if you turn in more, the pace is pretty comfortable if you don't check in every day, and since everyone has to be a little bad (they're monsters, after all) Orochimaru would have a lot of room to be a bad guy.

It is a power loss game, in the sense that you lose your original canon powers... but with the onset of transformation, they get replaced by shiny new ones, so you're definitely not stuck powerless. There's even a snake possibility for the monsters, if you wanted to stay true to Orochimaru's nature.