Hey, no cast or anything to offer really, but I was really jazzed to see some of the characters of your list (I love Sens8, and I adore Isabelle and I have a Simon journal lying around that I never actually did anything with). If you're interested in a sci-fi game then maybe give The Legion a look? Here's a convenient summary straight from the mods:

thelegion is panfandom sci fi, superhero RP where characters are drawn into the world of the Legion of Superheroes, a year after most of the the Legion disappeared. They have to take on the role of Legionnaires to fight against cosmic threats, government corruption, and supervillains, so the people working on a way to get them home are free to do it. The game is meant to last only 1-2 years before it hits endgame, something like a tabletop RP.

Some details about it:

- comm-based on DW
- has a mix of player plot and overarching mod plot
- minimal power-nerfing and no power loss (powerless characters get powers)
- slow to medium pace